Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-Related Behavior
نویسندگان
چکیده
منابع مشابه
BDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects.
A common polymorphism of the brain-derived neurotrophic factor (BDNF) gene (Val66Met) has been implicated in anxiety, which is associated with lower vagal activity. We hypothesize that the BDNF Val66Met polymorphism may have a modulatory effect on the cardiac sympathovagal balance. A total of 211 healthy Chinese-Han adults (58 male, 153 female, aged 33.3 +/- 10.3 years) were recruited with thre...
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Brain-derived neurotrophic factor (BDNF) plays important roles in activity-dependent plasticity processes, such as long-term potentiation, learning, and memory. The recently reported human BDNF Val66Met (BDNF(Met)) polymorphism has been shown to lead to altered hippocampal volume and impaired hippocampal-dependent memory and is associated with a variety of neuropsychiatric disorders. There are ...
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Background—Most anxiety and depressive disorders are twice as common in women compared to men and the sex difference in prevalence typically emerges during adolescence. Hormonal changes across the menstrual cycle and during the postpartum and peri-menopausal periods are associated with increased risk for anxiety and depression symptoms. In humans and animals, reduced brain derived neurotrophic ...
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335 BDNF Genotype and Sleep Intensity—Bachmann et al Moreover, in adult rats, the degree of exploratory behavior predicts the level of BDNF as well as of SWA during subsequent sleep.10 Finally, pharmacological experiments such as injections of exogenous BDNF, an anti-BDNF antibody, and an inhibitor of tyrosine kinase B receptor, the high-affinity BDNF receptor, consistently suggest that this re...
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ژورنال
عنوان ژورنال: Science
سال: 2006
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1129663